摘要
目的探讨乳腺颗粒细胞瘤的临床病理特征及诊断和鉴别诊断。方法复习2例乳腺颗粒细胞瘤的临床病理资料进行病理形态和免疫组化观察。结果2例GCT无特殊临床症状及体征,细胞境界清楚,胞体宽大,胞浆丰富,充满大的嗜酸性颗粒,浸润性生长,瘤细胞S-100、NSE(+),CEA(-)。良性者不转移,预后好。结论乳腺颗粒细胞瘤较少见,临床、细胞学及冰冻快速病理检查均易误诊为恶性肿瘤,应提高对此疾病的认识,减少不必要的扩大手术。
Objective To study the histopathological characteristics, diagnosis, differential diagnosis and prognosis of Granular cell tumor of the breast. Methods Two cases of Granular cell tumor of the breast were studied by histopathological observation and immunohistochemical staining. Results No special clinical situations were found in two cases and the tumor was charsterized by clear cell boundary,aboundant cytoplasm, full of acidophilic granules and it also infiltrated beyond the edge of the main tumor. Immunohistochemical study demonstrated that tumor cells were reacted with S-100, NSE but negatively with CEA. Those benign ones do not metastasize and such patients have favorable prognosis. Conclusion GCT of the breast, a rarely tumor that can be misdiagnosed by frozen section, clinical and cytological tests. The disease should be enforced to study and avoid being operated excessively and unnecessarily.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2006年第9期665-666,共2页
Cancer Research on Prevention and Treatment
关键词
乳腺肿瘤
颗粒细胞瘤
免疫组化
Breast neoplasms
Granular cell tumor
Immunohistochemistry
