摘要
目的探讨pRb2/p130、cyclinD1和MUC1在食管鳞癌中的表达及意义。方法应用免疫组化法检测了pRb2/p130、cyclinD1和MUC1在16例正常食管粘膜上皮及60例食管鳞癌中的表达水平,分析它们与临床病理指标及其三者之间相关关系。结果食管鳞癌中pRb2/p130的低表达与癌组织分化程度、TNM分期、淋巴结转移、浸润深度有关;cyclinD1的高表达与癌组织的分化程度、淋巴结转移相关;MUC1的高表达与淋巴结转移相关;Kaplan-Meier生存分析表明pRb2/p130高表达组生存率高于低表达组(P=0.0032,LogRank检验);Cox比例风险模型分析显示pRb2/p130、淋巴结转移、癌组织的分化程度是食管鳞癌的独立预后指标。结论食管鳞状细胞癌中存在pRb2/p130的低表达以及cyclinD1和MUC1的高表达,促进了细胞的生长和肿瘤的发展,是食管癌发生发展中的重要事件。
Objective To investigate the expressions and significance of pRb2/p130, cyclinD1 and MUC1 in esophageal squamous cell carcinoma. Methods Immunohistochemical method was used to detect the expressions of pRb2/p130, cyclinD1 and MUClin 16 cases of normal mucosae epithelium of esophagus and 60 cases of squamous cell of esophageal carcinoma. Results Low pRb2/p130 expression in squamous cell of esophageal carcinoma was significantly associated with tumor differentiation. TNM stages, lymphnode metastasis and depth of invasion; Overexpression of cyclinD1 was significantly associated with tumor differentiation, lymph-node metastasis. Overexpression of MUC1 was significantly associated with lymph-node metastasis;Kaplan-Meier analysis showing that the cumulative survival for patients with high pRb2/p130 expression is significantly higher than that of the low pRb2/p130 expression group. （P = 0.0032, by the log-rank test）. Multivariate analysis was performed using the Cox model. In the analysis, pRb2/p130,lymph-node metastasis and tumor differentiation were recognized as independent prognostic factors. Conclusion pRb2/p130 lowexpression but cyclinD1 and MUC1 overexpression in esophageal squamous cell carcinoma may promote the cells growth and cancer development, and are major events of tumor development.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2006年第9期649-652,共4页
Cancer Research on Prevention and Treatment
