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霉酚酸酯对狼疮性肾炎治疗作用的研究进展 被引量:1

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摘要 狼疮性肾炎是系统性红斑狼疮常见的并发症,传统的治疗以环磷酰胺和糖皮质类固醇激素为主,但部分患者反应不佳及其毒副作用限制了环磷酰胺的应用。霉酚酸酯是近年开发出来的一种新型免疫抑制剂,多项临床试验结果表明霉酚酸酯在狼疮性肾炎的诱导和(或)维持治疗阶段均能有效及安全地控制狼疮活动,减少蛋白尿,降低血清中自身抗体滴度,改善肾脏病理等,其副作用相对较少,并且没有致突变作用。
作者 王珍 徐安平
出处 《国外医学(内科学分册)》 2006年第9期369-371,408,共4页 Foreign Medical Sciences(Section of Internal Medicine)
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参考文献19

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