摘要
目的：评价VVI起搏治疗遗传性长QT综合征的疗效。方法：对23例有尖端扭转性室速发作,且经正规药物治疗无效或无法耐受的遗传性长QT综合征患者,植入了VVI起搏器。随访这23例患者术后心电图及心脏事件发生率。结果：QT间期平均值由术前(638．0±55．7)ms缩短至术后的(471．3±48．9)ms,QTc平均值为由0．627±0．07缩短至0．519±0．06。心脏事件的发生率由术前的(0．353±0．46)次/年降至术后(0．111±0．24)次/年,(P=0．039)。其中77．5%的患者随访期间无晕厥或猝死等心脏事件发生。90．91%患者存活。2例患者因尖端扭转性室速恶化为室颤抢救无效死亡。结论：VVI起搏治疗可以有效地减少长QT综合征患者恶性心律失常的发生,是治疗长QT综合征的重要方法之一。
Objective： To evaluate the efficacy of permanent cardiac-pacing for treatment in patients with congenital long QT syndrome, Methods：23 congenital long QT syndrome patients who oceured torsade de points and failed to respond or intolerable to drugs were implanted VVI permanent cardiac pacemakers. The electrocardiogram and heart events were observed after the pacemaker implantation. Results：After pacemaker implantation, average QT interval was shortened from （638.0±55.7）ms to （471.3 ± 48.9）ms （P=0. 00025）, QTc interval from （0. 627± 0.07）ms to （0. 519± 0.06）ms （P=0. 00025） and the rate of recurrent cardiac events was significantly reduced from 0. 353 ±0.46/yr to 0. 111 ± 0.24/yr （P=0. 039）. During follow up, 90.91% patients were alive, 77.5% patients had no cardiac events occurred and 2 patients died of TDP. Conclusions： Permanent VVI cardiac-pacing is one of the effective methods in the treatment of congenital LQTS patients by reducing malignant arrhythmia.
出处
《国际心血管病杂志》
2006年第5期349-351,共3页
International Journal of Cardiovascular Disease
