摘要
目的:探讨淋巴细胞浸润在扁平苔藓(LP)发病机制中的作用。方法:免疫组织化学SP法对32例LP患者及30例正常人皮肤CD3,CD4,CD8,CD20进行检测。结果:表皮中浸润细胞以CD3+T,CD8+T细胞为主,真皮以CD3+T,CD4+T,CD8+T细胞为主,真皮乳头浸润细胞多于表皮突。随病程延长,浸润细胞数减少(P<0.01),真皮CD4+/CD8+值下降(P<0.05),CD20+B细胞百分率上升(P<0.05)。有过度增殖性改变的皮损中CD20+B细胞明显增多。结论:CD8+T细胞与LP皮损的基底细胞损伤以及皮损的持续存在有关。皮损局部CD4+T,CD8+T细胞功能失衡。CD20+B细胞可能与疾病的持续存在及局部过度增殖性改变有关。
Objective： To investigate the role of infiltrating lymphocytes in the cutaneous lesions of lichen planus （LP）. Methods： The expressions of CD3, CD4, CD8, and CD20 were detected by immunohistochemical SP method in 32 LP patients with cutaneous lesions and 30 normal subjects. Results： In the epidermis, the infiltrating lymphocytes were mainly CD3^＋ and CD8^＋ T cells and CD20^＋ B cells were found by chance. The predominant cells in the dermis were CD3^＋ , CD4^＋, and CD8^＋ T cells. With the prolongation of the disease course, the number of infiltrating lymphocytes in the cutaneous lesions reduced （ P 〈0.01 ） , the ratio of CD4^＋ to CD8^＋T cells in the dermis decreased （ P 〈 0.05 ）, and the proportion of CD20^＋ B cells increased （ P 〈 0.05 ）. The number of CD20^＋ B cells markedly increased in LP patients with hyperplastic changes. Conclusion： CD8^＋ T cells are associated with the cutaneous lesions of LP. Imbalance of CD4^＋ and CD8^＋ T cells exists in the cutaneous lesions. CD20^＋ B cells may be related to the continuous immune response and excessively hyperplastic changes in the cutaneous lesions of LP.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2006年第4期427-428,共2页
Journal of China Medical University
关键词
扁平苔藓
淋巴细胞
CD
lichen planus
lymphocyte
lymphocytes
