摘要
目的评价阿托伐他汀钙片(立普妥)治疗原发性高胆固醇血症的疗效。方法将76例原发性高胆固醇血症患者随机分为两组：研究组43例(立普妥片10mg,每晚1次),对照组33例(辛伐他汀片20 mg,每晚1次),两组疗程均6周；分别检测服药前后的血脂变化,并进行比较。结果两组总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白胆固醇(LDL-C)分别下降(37．06%、22．05%)、(24．81%、14．49%)、(42．30%、28．30%)(P＜0．01)；高密度脂蛋白胆固醇(HDL-C)分别上升7．80%、7．13%(P＞0．05),总有效率分别为95．35%、90．91%。结论立普妥治疗原发性高胆固醇血症疗效高、不良反应少、安全可靠。
Objective To evaluate the curative effect of the atorvastatin calcium tablet（trade name：lipitor） in curing essential hypercholesterolemia. Methods 76 patients with essential hypercholesterolemia were divided into two groups randomly： 43 patients in the research group（lipitor tablet 10mg, qn）;33 patients in the comparison group （simvastatin tablet 20mg,qn）. The period of treatment for both two groups was 6 weeks. The changes of blood fat were detected before and after taking the medicine. The curative effect were compared at the same time. Results The total cholesterol（TC） of the research groups decreased by 37.06 % ,the TC of the comparison group decreased by 22.05 %. The triacylglyceride（TG） of the research group decreased by 24.81%, however, the TG of the comparison group decreased by just 14.49%. The low-density lipoprotein cholesterol（LDL-C） of the research group decreased by 42.30% while the comparison group just decreased by 28.30% （ P 〈 0.01 ）. Also, the high-density lipoprotein cholesterol（HDL-C） of the research group increased by 7.80 % , and the comparison group increased by 7.13 % （P 〉0.05）. The effective rate of the research group was 95.35 %. For the comparison group, the effective rate was 90.91%. Conclusion The lipitor has a good curative effect in curing essential hypercholesterolemia. Also, the lipitor has fewer side effect. This medicine is safe and reliable for patients.
出处
《中国基层医药》
CAS
2006年第8期1309-1310,共2页
Chinese Journal of Primary Medicine and Pharmacy
