摘要
2002～2004年每年9～11月在兰州市对我省使用流感疫苗进行血清学考核，3年用血凝抑制试验（HI）分别检测44、52、49人疫苗免疫前后不同4种血清型流感病毒的抗体水平。结果显示，接种疫苗者30～35d后流感病毒4个血清型流感病毒HI抗体均有不同程度的增长，H1N1、H3N2、B（Yamagata）、B（Victorian）保护率（≥1．40）分别为91．72％、91．72％、81．63％和59．38％；免疫后人体HI抗体滴度的几何均数（GMT）分别为1：221．76、1：189．58、1：71．04和1：43．04；较接种前HI抗体滴度≥4倍的分别占53．79％（78／145）、58．62％（84／145）、75．51％（37／49）和58．37％（56／96）。血清学检测表明流感疫苗免疫效果好，免疫成功率高。
In order to observe the immunological efficacy of influenza virus vaccine in between September and November from 2002 to 2004 in Lanzhou, Gansu Province of China, 44,52 and 49 healthy persons inoculated the vaccine were evaluated in each period of time respectively. The serum samples were collected before and after vaccination, antibodies were determined by HI （haemagglutination inhibition ） test. The result showed that HI antibodies related to four serotypes of influenza virus were increased with different levels during 30 ～ 35 days after vaccination. The ratios for protection （ ≥1 ： 40 ） of four subtype virus [H1N1, H3N2,B2 （ Victoria）, B1 （Yamagata） ] were 91.72%, 91.72%, 71.03%, and 59.38% ; GMT were 1： 221.76, 1： 189.58, 1： 71.04, and 1： 43.04;the increasement more than 4 folds for HI antibodies titers were 53.79% （ 78/145 ）, 58.62% （ 84/145 ）, 58.37% （ 56/96 ） and 75.51% （ 37/49 ） after vaccination respectively. It shows that this vaccine has an excellent immunization efficacy and exerts success in protection.
出处
《微生物学免疫学进展》
2006年第3期18-22,共5页
Progress In Microbiology and Immunology
关键词
流感疫苗
免疫效果
血凝抑制抗体
Influenza virus vaccine
Immune effect
HI antibody
