摘要
目的探讨Miller-Fisher综合征的临床特点。方法回顾分析12例Miller-Fisher综合征患者的临床特点。结果主要神经系统症状:头昏,视物成双,四肢无力,手足发麻感,头痛。主要神经系统体征:瞳孔直接及间接对光放射消失,双侧眼外肌麻痹,水平眼震,周围性面瘫,共济失调,深、浅感觉减退,腱反射减弱或消失。首发症状主要表现为视物成双和四肢无力,脑脊液蛋白升高10例,脑脊液细胞升高2例。肌电图检查示神经源性损害3例,CT和MRI检查均未发现异常。甲基强的松龙和人血免疫球蛋白同时使用可有效缓解病情,10例患者出院后随访3个月内症状消失。结论Miller-Fisher综合征主要累及周围神经系统,大多数患者预后良好。
Objective To study the clinical characteristics of Miller-Fisher syndrome. Methods We retrospectively analyzed the patients with a diagnosis of Miller-Fisher syndrome, who had been admitted to our hospital from 1993 to 2005. They all met criteria for Miller-Fisher syndrome. Results The major sympotoms of nervous system included dizziness, double vision, weakness, paraesthesia of extremity, and headache. The major physical sign included： disappearance of pupil direct and indirect light reflex, ophthalmoplegia externa, nystagmus, ataxia, hypesthesia, peripheral facial paralysis, and weak or disappeared tendons, initial symptoms included： double vision and weakness. Increased total protein （10 patients） and the number of cells （2 patients） was detected in the cerebrospinal fluid. Tree patients were found auxiliary fibers injury in electromyologram （EMG）. There was no positive findings in computer tomography （CT） or magnetic resonance imaging（MRI）. It had good therapeutic effect by use immunoglobulin, 10 patients symptoms disappeared in 3 months by telephone follow-up. Conclusions Miller-Fisher syndrome mainly involves peripheral nervous system, and has good prognosis,
出处
《中国神经免疫学和神经病学杂志》
CAS
2006年第5期307-309,共3页
Chinese Journal of Neuroimmunology and Neurology
基金
军队"十五"医药卫生重点课题资金资助项目(MZ01041)
