摘要
Testin又称睾丸素,最初是从小鼠睾丸支持细胞增菌培养基中鉴定的一种分泌性糖蛋白,可通过受体联合蛋白与细胞表面紧密结合。通过对睾丸素的研究,人们发现睾丸素mRNA分布于全身大多数器官,尤其以睾丸和卵巢表达最高。研究表明睾丸素可能为一种抑癌基因,且当睾丸素基因表达降低或缺失时,致癌物诱导的胃癌发生率更高。
Testin is named testosterone. It is a kind of secretory glycoprotein identified initially from sertoli cell enriched medium. It can be connected tightly with cell surface by acceptor association protein. Testin mRNA is expressed in all normal human tissues, especially in testis and oval. Our findings suggest that testin may represent a candidate tumor suppressor gene. When testin expression is degrade or deleted, the carcinogen-induced carcinoma incidence will be higher.
出处
《国际病理科学与临床杂志》
CAS
2006年第4期367-368,共2页
Journal of International Pathology and Clinical Medicine
