摘要
轴突生长的抑制因素是中枢神经系统受损后再生困难的主要原因之一。髓鞘相关糖蛋白(MAG),Nogo蛋白和少突胶质细胞-髓鞘糖蛋白(OMgp)是3种主要的髓鞘相关抑制因子(MAIFs)。Ephrin-B3是另外一种髓鞘相关抑制因子。Nogo受体,p75受体和LINGO-1组成Nogo受体复合体。Rho-A和蛋白激酶C是MAIFs发挥轴突生长抑制作用的重要胞内分子。拮抗MAIFs或是阻断MAIFs的信号通路,可促进中枢神经损伤后的轴突再生。
The presence of some inhibitory mediators such as mvelin-associated glycoprotein,Nogo protein and oligodendrocyte-myelin glycoprotein is one of reasons of the difficulty of axon regeneration after the injury of adult central nervous system（CNS）Epbrin-B3 is another identified myelin-based inhibitor of neurite outgrowth,There are no less than three elements in the Nogo receptor complex：the Nogo receptor ,the p75 receptor （p75NTR）and LINGO-1.Rho-A and conventional protiein kinase C have been identified to be necessary components for the axon growth inhibition induced by Myelin-associated inhibitor factors（MAIFs）,Many strategies have been studied to treal CNS injuries,such as spinal cord injuries（SCI）,either blocking MAIFs or blcking MAIF signaling.
出处
《国际病理科学与临床杂志》
CAS
2006年第4期343-346,共4页
Journal of International Pathology and Clinical Medicine
基金
广东省科技计划资助项目(2005B50301012)
关键词
中枢神经系统
再生
髓鞘
NOGO
脊髓损伤
central nervous system
regeneration
myelin
Nogo
spinal rord injury
