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慢性槲皮素增强小鼠空间学习记忆 被引量：2

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摘要 利用小鼠D-半乳糖衰老模型,通过Morris水迷宫(MWM)等动物行为实验和小鼠皮层与海马组织还原型谷胱甘肽和羟自由基含量测定等生化指标实验,对槲皮素延缓脑衰老作用和机制进行了研究.实验结果表明,槲皮素能提高D-半乳糖衰老模型小鼠的空间搜索学习和记忆能力,这些作用与槲皮素改善衰老小鼠皮层和海马的功能、抑制氧化应激反应有关,与增加还原型谷胱甘肽含量以减少羟自由基含量有关.为充分利用槲皮素作为一种天然的抗衰老药物奠定了良好的实验基础.
作者 刘建才 余胡清 宁新宝
机构地区 南京大学电子科学与工程系生物医学电子工程研究所近代声学国家重点实验室 南京大学生物科学与技术系
出处 《中国科学（C辑）》 CSCD 北大核心 2006年第4期378-384,共7页 Science in China(Series C)
基金 江苏省药用植物重点实验室开放基金资助项目(批准号:KJS03078)
关键词 槲皮素 衰老 学习记忆 自由基 活性氧 还原型谷胱甘肽
分类号 R285 [医药卫生—中药学]
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参考文献14

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共引文献40

同被引文献15

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二级引证文献6

中国科学（C辑）
2006年 第4期

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