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细胞外基质金属蛋白酶诱导因子对细胞滋养细胞分泌基质金属蛋白酶的调节 被引量:6

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摘要 胎盘植入和胎盘形成过程中,滋养细胞向母体子宫内膜有节制的浸润是细胞外基质降解和重建的关键步骤,基质金属蛋白酶(matrix metalloproteinases,MMP)在这一过程中发挥重要作用。细胞外基质金属蛋白酶诱导因子(extracellular matrix metalloproteinase inducer,EMMPRIN)是免疫球蛋白超家族的成员之一,能刺激与肿瘤有关的成纤维细胞和肿瘤细胞自身的MMP显著增加。最新的研究发现,在足月妊娠妇女的胎盘和胎膜组织中有高水平的EMMPRIN表达,推测与维持妊娠和发动分娩有关。作为MMP的上调因子EMMPRIN,在妊娠早期胎盘绒毛组织中的表达未见报道。本研究采用高纯度的原代细胞滋养细胞体外培养模型,探讨EMMPRIN在胎盘绒毛组织中的表达变化及其对细胞滋养细胞分泌MMP的调节作用。
出处 《中华妇产科杂志》 CAS CSCD 北大核心 2006年第8期560-562,共3页 Chinese Journal of Obstetrics and Gynecology
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参考文献13

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二级参考文献8

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引证文献6

二级引证文献28

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