摘要
目的探讨盐酸米多君和盆底肌肉锻炼治疗压力性尿失禁(SUI)的临床效果。方法采用单中心、前瞻性随机对照的研究方法,对46例SUI患者进行治疗效果的评价,其中服用盐酸米多君22例(药物组),进行盆底肌肉锻炼24例(锻炼组)。根据治疗前后患者主观和客观临床参数进行疗效评价,并进行治疗前后生活质量评分。结果药物组2例及锻炼组4例患者未按要求完成治疗。根据患者主观临床参数评价SUI的治疗结果,药物组显效率为15％(3／20),有效率为85％(17／20);锻炼组有效率为55％(11／20),无效率为45％(9／20)。根据患者客观临床参数——1 h尿垫试验结果评价SUI的治疗结果,药物组平均溢尿量减少4．2 ml,锻炼组减少0．6 ml,两组比较,差异有统计学意义(P<0．01)。药物组患者治疗后生活质量评分平均提高21分,锻炼组平均提高9分,两组比较,差异有统计学意义(P<0．05)。药物组14例患者及锻炼组24例患者治疗前后性生活质量评分无变化。结论盐酸米多君和盆底肌肉锻炼均为非手术治疗SUI的有效方法;盐酸米多君的治疗效果优于盆底肌肉锻炼。
Objective To evaluate the therapeutic results of α-adrenoceptor agonists and pelvic floor muscle exercises （PFME） for stress urinary incontinence. Methods A prospective, single-center, random control study was carried out in 46 patients with stress urinary incontinence （ SUI ）. The patients were divided into two groups, 22 in α-adrenoceptor agonists group vs 24 in PFME group. Clinical outcomes and the scores of quality of life were evaluated and compared between the two groups. Results Two patients in α-adrenoeeptor agonists group and four patients in PFME group, were failed to complete the study. According to patient＇s subjective scores, excellent effective rate was 15 % （3/20） and effective rate was 85% （17/20） in α-adrenoceptor agonists group versus effective rate of 55% （11/20） and no-effective rate of 45% （9/20） in PFME group. According to objective 1 h pad test criteria, the efficacy was significantly better in α-adrenoceptor agonists group （ P 〈 0. 01 ）. The scores of quality of life were improved in all patients of two groups after treatment, and were significantly better in α-adrenoeeptor agonists group （P 〈 0. 05 ）. There was no difference in sexual life score in PFME group and α-adrenoceptor agonists group. Conclusions Both α-adrenoceptor agonists and PFME are effective non-surgical treatments for stress urinary incontinence. However, α-adrenoceptor agonists have better effect than PFME.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2006年第8期537-539,共3页
Chinese Journal of Obstetrics and Gynecology
关键词
肾上腺素能α激动剂
盆底肌锻炼
尿失禁
压力性
Adrenergic alpha-agonists
Pelvic floor muscle exercise
Urinary incontinence, stress
