期刊文献+

手性4-哌啶酮衍生物的合成 被引量:3

Synthesis of Chiral 4-Piperidones
在线阅读 下载PDF
导出
摘要 哌啶酮及其衍生物是一类非常重要的医药、农药和化工中间体。采用手性羟胺类化合物(手性试剂)与丙烯酸甲酯反应成功地合成了几个新的含羟基的手性N取代4-哌啶酮类化合物,采用核磁共振波谱对其结构进行了表征。 Piperidones and its derivatives are a class of compounds with pharmaceutical and agricultural importance. Several new chiral compounds of N-substituted 4-piperidones were obtained from chiral reagent hydroxylamines and methyl acrylate. Their structures were proved by ^1H NMR and ^13C NMR.
出处 《化学工业与工程》 CAS 2006年第5期396-399,共4页 Chemical Industry and Engineering
关键词 哌啶酮 手性试剂 羟胺 手性化合物 piperidone chiral reagents : hydroxylamine chiral compounds
  • 相关文献

参考文献8

  • 1COMINS D L, BROOKS C A, INGALLS L. Reduction of n-acyl-2,3-dihydro-4-pyridones to n-acyl-4-piperidones using zinc/acetic acid[J] .J Org Chem,2001,66:2 181 - 2 182.
  • 2DIMMOCK R, EALIAS D W, BEAZELY M A, et al.Bioactivities of chalcones [ J ] . Curr Med Chem, 1999, 6 :1 125-1 149.
  • 3DIMMOCK J R, KANDEPU N M, NAZARALI A J, et al.Conformational and quantitative structure-activity relationship study of cytotoxic 2-arylidenebenzocycloalkanones[J] .J Med Chem,1999,42(8) :1 358-1 366.
  • 4MCELVAIN S, STORK G, PIPERIDINES DERIVATIVES X V. The preparation of l-benzoyl-3-carbethoxyl-4-piperidone,a synthesis of guvacine[J] .J Am Chem Soc, 1946,68(6) :1 049-1 053.
  • 5BALIAH V, JEYARAMAN R, CHANDRSEKARAN L.Synthesis of 2, 6-disubstituted piperidines, oxanes, and thianes [ J ] . Chem Rev, 1983,83 (4) : 379 - 423.
  • 6STORK G, MCELVAIN S M. Preparation of ethyl β-benzylaminopropionate and benzyl-di-(β-carbethoxyethyl )-amine[J] .J Am Chem Soc, 1947,69( 1 ) :971 - 972.
  • 7PRILL E A, MCELVAIN S M. A study of the cyclization ofseries of ω,ω'-dicarbethoxydialkylmethylamines through the acetoacetic ester condensation I J~ .J Am Chem Soc, 1933,55:1 233-1 241.
  • 8陆文超,李瑛琦,郭春.1-苄基-4-哌啶酮的合成工艺改进[J].辽宁化工,2003,32(1):1-2. 被引量:6

二级参考文献6

  • 1Shiro Morosawa.Studies on seven-membered HeterocyclicCompounds Containing Nitrogen Ⅱ.An Improved Synthesis of 1-azacycloheptan-4-one and Its Related Compounds[J].Bull Chem,1958,31(4):418-422
  • 2Gilbert Stork,McElvain SM.Prepartion of Ethylβ-Benzyl-amine Propionate and Benzyl-di-(β-Canbethoxyethyl) -amino[J].J Am Chem Soc,1947,69(1):971 -972
  • 3Bolyard N W.Catalytic Reduction of 1-Phenyl nad 1-Benzyl -4-Piperidones[J].J Am Chem Soc,1930,52(2):1030-1032
  • 4国家医药管理局.全国原料药工艺汇编[M].北京,人民卫生出版社,1980:820-822
  • 5David R Howton,1,3-Dimethylpiperdone-4[J].J Org Chem,1945,10:277-282
  • 6Prill E A,McElvain S M.A Study of the Cylization of A Series of ω,ω'-Dicarbethoxydialkylamines through the Acetoacetic Ee-the Condensstion[J].J Am Chem Soc,1933,55:1233-1241

共引文献5

同被引文献22

引证文献3

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部