摘要
目的 探讨联合应用外源性肺表面活性物质（PS）和保护性肺通气策略对新生儿胎粪吸入综合征的治疗效果。方法 新生儿胎粪吸入综合征35例经气管插管应用外源性PS（200mg／kg），随机分为A和B两组，A组18例采用常规机械通气治疗；B组17例保护性肺通气治疗。观察两组患儿的临床转归，并监测24h内PaO2、氧合指数（OI）。结果 与以往同类病例的治疗结果相比，本组患儿病死率（5.71％）显著降低，并发症显著减少。在治疗后24h内的各个时点OI显著低于A组（P〈0．05～0.01）。结论 外源性PS与保护性肺通气具有协同作用，二者联合应用可明显提高MAS的疗效．且并发症显著降低。
Objective To assess the efficacy of exogenous pulmonary surfaetant（PS） combined with protective lung mechanical ventilation on meconium aspiration syndrome（ MAS）. Methods Thirty five infants with MAS received PS（200 mg/kg） via tracheal intubations were randomly divided into group A and B. All 18 infants in group accepted conventional mechanical ventilation; however, 17 patients from group B were performed by protective lung mechanical ventilation. To observe the clinical manifestation and detect the changes of PaO2 and oxygenation index （ OI） within 24 h after treatment in patients. Results The mortality（5.71%） and complications in the patients of group B were less than that in group A. The OIs of group B were lower than those of group A during various time after treatment. （ P 〈 0.01） . the oxygenation index in groups B was signifieantly lower than that in group A （ P〈0.01）. Conclusions The combination of exogenous PS with protective lung mechanical ventilation exerts synergistic action on the MAS, could increase curative effect and decrease incidence of complications.
出处
《实用全科医学》
2006年第6期645-646,共2页
Applied Journal Of General Practice
关键词
肺表面活性物质
机械通气
新生儿
胎粪吸入综合征
Pulmonary surfactant
Mechanical ventilation
infant
Meconium aspiration syndrome
