摘要
我们建立了犬脑干缺血模型，以ＢＡＥＰ和组织病理（光镜和电镜）改变作指标，观察了氟桂嗪（ＦＮＺ）对脑干缺血性损伤的保护作用。结果发现，对照组ＢＡＥＰ和病理恢复率分别是３５．７％和３２．１％，而ＦＮＺ保护组的恢复率分别是６９．６％和６４．３％，两组间有显著性差异（Ｐ＜０．０１）。表明ＦＮＺ对犬脑干缺血确有较好的保护作用。
To evaluate protective effects of flunarizine(FNZ) on ischemic brainstem injuries,we established brainstem ischemia models in dogs and observed the changes of BAEP and histopathology.Results showed that after 12h ischemia,recovery ratios of BAEP and pathologic outcome were 35.7% and 32.1% respectively in control groups,while in FNZ groups,69.6% and 64.3% respectively.There were significant difference between FNZ treated group and control group ( P <0.01).It suggests that FNZ has protective effect on ischemic brainstem injuries.
出处
《临床神经病学杂志》
CAS
1996年第6期329-331,共3页
Journal of Clinical Neurology
关键词
脑干缺血
氟桂嗪
组织病理学
BAEP
Brainstem ischemia Flunarizine Brainstem auditory evoked potentials Histopathology
