摘要
【目的】观察参附注射液(Shen FuInjection,SFI)对泰素联合顺铂(TP)化疗方案治疗非小细胞肺癌的减毒作用。【方法】45例拟行TP方案化疗的非小细胞肺癌患者,随机分为参附注射液先治疗组(23例)和参附注射液后治疗组(22例)。通过随机自身前后交叉对照,观察参附注射液对TP方案毒性的影响。【结果】总体SFI+TP方案的白细胞和中性粒细胞毒性、恶心呕吐症状均较TP方案轻(P<0.01),其中参附注射液先治疗组SFI+TP方案的白细胞和中性粒细胞毒性、恶心呕吐症状均较TP方案轻(P<0.01),参附注射液后治疗组SFI+TP方案恶心呕吐症状较TP方案轻(P<0.05)。两方案其他毒性比较均无显著性差异(P>0.05)。【结论】参附注射液能减轻TP方案治疗非小细胞肺癌的血液学毒性和胃肠道毒性;早期联合应用参附注射液的减毒作用更好。
[Objective] To observe the attenuation of Shen Fu Injection （SFI） on regimen of taxol plus cisplatin （TP） in treating non-small cell lung cancer （NSCLC）. [ Methods ] Forty-five patients with NSCLC were given at least two cycles of TP regimen. Twenty-three NSCLC patients （group A） of 45 were given SFI before TP treatment and the other 22 pateints （group B） were given SFI after TP treatment. The effect of SFI on the toxicity of TP was observed by a randomized self-controlled trial. [ Results] Side reactions such as leukopenia, neutropenia, and nausea and vomiting were relieved in patients treated by SFI ＋ TP therapy as compared with those by TP therapy only （P 〈 0.01 ）, and the above side reactions were milder in group A than those in group B （ P 〈 0.05 or P 〈 0.01 ）. The difference of other toxicity of SFI ＋ TP therapy and TP therapy was insignificant （ P 〉 0.05）. [ Conclusion ] SFI has an effect in reducing hematological toxicity and toxicity of gastrointestinal tract of TP therapy for NSCLC, and the attenuation of SFI is better when it is used with TP as early as possible.
出处
《广州中医药大学学报》
CAS
2006年第5期387-390,共4页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
卫生部"999"参附注射液中药科研基金(编号:2003001)
加拿大TerryFox慢跑癌症科研基金(2004)
