摘要
目的探讨重症药疹发生发展的规律。方法按年代、型别、致敏药物分类,回顾性分析191例重症药疹患者的临床资料。结果剥脱性皮炎组的患病年龄超过中毒性表皮坏死松解组及重症多型红斑组。肺炎、败血症、消化道出血、电解质紊乱是常见的并发症。抗生素致敏患者年龄大于抗癫痫药所致者．且抗癫痫药致敏者潜伏期长于其他类药物。结论解热镇痛药、磺胺、抗生素为主要致敏药物。不同年代、不同型别及不同药物所致重症药疹均有其特殊性。
Objective To explore the general rule of the development of severe drug eruptions. Methods Clinical data were retrospectively collected from 191 cases of severe drug eruptions, and classified according to time, types and causative drugs. Results The mean onset age of exfoliative dermatitis was older than that of toxic epidermal necrolysis and Steven-Johnson syndrome. Pneumonitis, septicaemia, alimentary tract hemorrhage and electrolyte disturbances were common complications. The mean age of patients with drug eruptions caused by antibiotics was older than that by antiepileptics. The latent period of eruptions caused by antiepileptics was longer than that by the other drugs. Conclusions The predominant causative drugs of severe drug eruptions are antipyretic analgesics, sulfonamides and antibiotics. Characteristic manifestations are observed for servere drug eruptions at different time, of different types and by different causative drugs.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2006年第9期530-532,共3页
Chinese Journal of Dermatology
关键词
药疹
病例分析
Drug eruptions
Clinical analysis
