摘要
目的:探讨环氧化酶-2(COX-2)蛋白与P糖蛋白(P-gp)在乳腺癌组织中表达的相关性。方法:应用免疫组织化学染色法,检测32例乳腺癌组织中COX-2蛋白与P-gp蛋白的表达情况。结果:32例乳腺癌组织中COX-2表达阳性率为62·5%(20/32),P-gp表达阳性率为46·9%(15/32),两者表达呈正相关性(r=0·598,P<0·05)。结论:乳腺癌组织中COX-2与P-gp表达呈正相关,COX-2可干预P-gp的表达并参与乳腺癌多药耐药(MDR)的调节。
Objective：To study the expression of cyclooxygenase-2 （COX-2） and P-glycoprotein （P-gp） in breast cancer. Methods： Expression of COX-2 and P-gp was detected in 32 cases of breast cancer tissue by immunohistochemistry. Results： The positive COX-2 expression was 71.9% in breast cancer, and the positive P-gp was 46. 9%. The expression of COX-2 in P-gp positive breast cancers was significantly higher than that in P-gp negative breast cancers. Conclusion： The expression of COX-2 was significantly correlated with P-glycoprotein. COX-2 might play a crucial role in mediation of multidrug-resistance （MDR） in breast cancer.
出处
《临床肿瘤学杂志》
CAS
2006年第8期604-606,611,共4页
Chinese Clinical Oncology
关键词
乳腺癌
COX-2
P—gP
多药耐药
Breast cancer
Cyclooxygenase-2
P-glycoprotein
Multidrug-resistance
