摘要
目的:介绍第二代抗精神病药物中第一个长效注射剂利培酮用于临床治疗精神分症的研究进展。资料来源:应用计算机检索Medline2003-01/2005-11期间与利培酮长效注射剂有关的文章,检索词为“RisperidoneLong-actingInjection”或“RisperdalConsta”。限定文章语言种类为English,研究对象为人类。资料选择:对资料进行初审,选择随机对照研究和临床研究作为纳入条件。排除综述、个案报道、经验总结、临床指南等文献。资料提炼:共收集符合条件的文献26篇,排除药代动力学研究文献3篇,类似文献4篇,选择符合本课题的要求的19篇文献进行综述。资料综合:利培酮长效注射剂是治疗精神分裂症和分裂情感性精神病安全有效的新型药物,不良反应少,可以由口服抗精神病药物或第一代抗精神病药物长效注射剂安全地换用利培酮长效注射剂治疗。老年患者同样安全有效,无种族差异。同时具有显著的药物经济学价值,可改善患者的生活质量。结论:利培酮长效注射剂是治疗精神分裂症和分裂情感性精神病安全有效的新型药物。
OBJECTIVE： To introduce the research development of the first long-acting injection in the second-generation antipsychotic＂ rlsperidone in treating schizophrenia, DATA SOURCES： A computer-based online search of Medline was undertaken to identify articles about the risperldone long-acting injection published in English from January 2003 to November 2005 by using the keywords of ＂Risperldone Long-acting Injection＂ or ＂Risperdal Consta＂, with human as the subjects. STUDY SELECTION： The data were preliminarily checked and the literatures about ＂clinical trial＂ and ＂randomized controlled trial＂ were ineluded, and those literatures such as review articles, case reports, academic summary and clinical guide were excluded. DATA EXTRACTION： Totally 26 literatures were collected. Excluding 3 pharmacoklnetic literatures and 4 repetitive literatures, 19 of them were accorded with the inclusive criteria. DATA SYNTHESIS： Risperidone long-acting injection is a reliable and effective new medicine in treating schizophrenia and schizoaffective psychosis with few adverse reactions. It can be used by replacing the oral taken antipsychotics or the first-generation antipsychotlcs long-actlng injection. Risperidone long-acting injection is also safe and effective for the elderly and without race distinction, It is a cost saving therapeutic option for patients with schizophrenia and can improve the quality of life of patients with schizophrenia. CONCLUSION： Risperidone long-acting injection provides a new and promising therapeutic option for the treatment of schizophrenia and schizoaffective disorder.
出处
《中国临床康复》
CSCD
北大核心
2006年第34期142-144,共3页
Chinese Journal of Clinical Rehabilitation
