摘要
应用PCR-RFLP技术及基因测序方法检测大连地区汉族人2型DM患者[动脉粥样硬化(AS)组110例,非AS组120例]线粒体DNA(mtDNA)16189位点变异。As组mtDNA 16189T→C变异率高于非AS组(35．5％vs20．0％,P<0．01)。mtDNA 16189 T→C变异组HOMA-IR和HbAIC高于非变异组(P <0．05)。因此,mtDNA 16189 T→C变异可能与胰岛素抵抗、较高血糖水平和2型DM早期AS相关。
PCR-RFLP and sequence analysis were used to detect the 16189 T to C variant of mitochondrial DNA （ mtDNA ） in 230 patients with type 2 diabetes mellitus （ DM ） including 110 cases with atherosclerosis （AS） and 120 cases without AS. The AS group showed a higher mtDNA 16189T→C variant rate than those in the non-AS group （35.5% vs 20.0% , P 〈0.01 ）. HOMA-IR and HbA1c in the variant group were higher than those in the non-variant group （ P 〈 0.05 or P 〈 0.01 ）. The variant of mtDNA 16189 T to C might be associated with insulin resistance, higher level of plasma glucose and earlier occurance of AS in type 2 DM.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2006年第4期354-355,共2页
Chinese Journal of Endocrinology and Metabolism
基金
"十五"国家科技攻关课题资助项目(2001BA702B01)
辽宁省科技厅科技攻关项目(2002225003-6)
辽宁省教育厅高等学校科学研究项目(202203266)
关键词
动脉粥样硬化
糖尿病
2型
线粒体
基因
Atherosclerosis
Diabetes mellitus, type 2
Mitochondria
Gene
