摘要
抗菌肽是具有抗菌活性的一类短肽,广泛存在于生物界,是先天免疫的重要防御成分,其杀细胞机制为在靶细胞膜上穿孔,靶细胞因渗透压改变而死亡。抗菌肽具有广谱抗菌活性,并有抗病毒、抗真菌、抗寄生虫及抗肿瘤等生物活性,有良好的应用前景,使其走向临床的最大挑战是如何用基因工程技术低成本大量生产抗菌肽产品。该文综述了抗菌肽的原核表达研究进展及其应用前景。
Antimicrobial peptides （AMPs） are amphiphilic, positively charged molecules that have emerged as novel antimicrobial agents. Many different kinds of AMPs have been identified from various organisms. AMPs are key components of the innate immune system of most multicellular organisms. They have been shown to exert their activities directly through the lipid bilayer of the cell membranes. AMPs have broad spectrum of antibacterial activities and potent antimicrobial activities against viruses, fungi and protozoa, AMPs also exhibit anti-tumor activities. Nevertheless, preparation of AMPs at a large scale is a significant challenge in order to develop commercial products. This paper focuses on the advances of prokaryotic expres sion and potential applications of AMPs.
出处
《国际医学寄生虫病杂志》
CAS
2006年第4期206-210,共5页
International JOurnal of Medical Parasitic Diseases
关键词
抗菌肽
融合表达
大肠杆菌
转基因工程
Antimicrobial peptides （AMPs）
Fusion expression
Escherichia coli
Transgene engineering
