摘要
为了观察心肺移植病理形态特点，对３例心或／及肺移植患者心内膜心肌活检（ＥＭＢ）、支气管镜肺活检（ＴＢＬＢ）及２例尸检材料进行组织形态学研究。结果显示：心、肺移植排异反应及其分级与该器官间质、血管周围淋巴细胞浸润及浸润细胞多少有关，可无或伴有实质细胞损伤。例１原位心移植患者术后７个月猝死原因为移植心冠状动脉病变及急性重度排异反应。例２心肺联合移植患者术后早期并发冠状动脉血栓栓塞而死亡。例３单肺移植患者至今１６个月情况尚好，术后第１１、１３个月ＴＢＬＢ发现受体原发肺结节病在移植肺再发。ＥＭＢ及ＴＢＬＢ是心、肺移植排异监测的可靠有效的方法，组织学诊断排异反应对临床治疗及预后观察有重要意义。
Inordertoinvestigatethepathologicfeaturesofcardiacandpulmonaryalografts,en-domyocardialbiopsies(EMB)andtransbronchiallungbiopsies(TBLB)werestudiedin3patientsaf-terlungandhearttransplantation.2autopsyexaminationsafteracardiacandacombinedheartandlungtransplantationwereincludedinthisstudy.Theresultsdemonstratedthatthepresenceandtheseverityofalograftrejectionwerecloselyrelatedtothedegreeofinterstitialandperivascularlym-phocyteinfiltration.Parenchymalinjuriesmaysometimesbeaconcomitantsign.Onepatientsdiedsuddenly7monthsaftercardiactransplantationbecauseofacuteseverealograftrejectionincombina-tionwithalograftcoronarydisease.Anotherpatientwhoreceivedcombinedheartandlungtrans-plantdiedearlyaftertheoperationduetocoronarythromboembolism.Thepatientwhoreceivedasinglelungtransplanthasalreadysurvived16months.TBLBat11and13monthsaftertheoperationshowedtherecurranceofpulmonarysarcoidosisinthedonorlung.OurstudyconfirmedthatEMBandTBLBprovidedusefulinformationforacutealograftrejectionafterheartandlungtransplanta-tion.
出处
《中华病理学杂志》
CAS
CSCD
北大核心
1996年第6期361-363,共3页
Chinese Journal of Pathology
