摘要
用免疫组化法检测36例胰腺癌、15例胰腺癌转移淋巴结、10例慢性胰腺炎和12例正常胰腺组织P21的表达。发现胰腺癌P21染色阳性率为61%,高于正常胰腺组织(P<0.05),而与慢性胰腺炎组织比较则无显著差异(P>0.5)。P21阳性组的胰腺癌病例淋巴结转移率较阴性组高(P<0.05)。提示:①慢性胰腺炎与胰腺癌的相关性具有分子生物基础;②P21阳性的胰腺癌组织较易发生淋巴结转移。
In this study, 36 pancreatic adenocarcinomas, 15 lymph node metastatic samples from the above malignancies, 10 chronie pancreatitis and 12 normal pancretic samples were examined immunohistochemieally for expression of P21, The positive rate of pencreatic carcinomas was 61%, higher than the one of normal panoramas (P<0.05), but not significantly different from the one of chronic pancreatitis(P>0.5). Moreover, pancreatic carcinomas with positive P21 staining were. found to have higher lymph node metastatic rate (P<0.05). Thus, we explain the molecular biological basis of its association with pancreatic carcinomas. 2. Pancreatic care ers with postive P21 staining are apt to metastasize.
出处
《广东医学》
CAS
CSCD
1996年第12期796-798,共3页
Guangdong Medical Journal
