摘要
目的 观察紫杉醇（PTX）加顺铂（CDDP）联合化疗治疗晚期非小细胞肺癌的近期疗效及毒副反应。方法 PTX135～175mg／m^2静脉滴注,第1天；CDDP 75mg／m^2，分三次用完。每21天为1个周期，连用2或3周期。结果可评价疗效者37例，其中PR16例，总有效率为43．2％。毒副反应主要是骨髓抑制和恶心呕吐。结论．PTX＋DDP治疗晚期非小细胞肺癌可获得较高疗效，毒副反应轻，是一个较好的联合化疗方案。
Objective To evaluate the efficacy and toxicity of conbined chemotherapy with paclitaxel （PTX） plus cisplatin （DDP） in the treatment of advanced non-small cell lung cancer （NSCLC）.Methods From July 2003 to July 2005 37 patients with advanced non-small cell lung cancer received PTX 135～175mg/m2 by intravenous infusion, on day 1, and CDDP 75mg/m2 by intravenous infusion, in the following 3 days. The treatment period was 3 weeks per cycle for 2 or 3 cycles. Results Thirty seven patients were evaluable for efficacy. Sixteen patients got partial response with an overall response rate of 43. 2%, he main toxicities were myelosuppression and nausea. The other side effects were mild. Conclusion A high response rate can be obtained in advanced NSCLC by PTX plus DDP. PTX is a promising antitumor agent with tolerable toxicity.
出处
《临床肺科杂志》
2006年第2期166-167,共2页
Journal of Clinical Pulmonary Medicine
关键词
非小细胞肺癌
紫杉醇
顺铂
联合化疗
Non-small cell lung cancer
paclitaxel
cisplatin
combined chemotherapy
