摘要
目的:观察硫酸镁溶液辅助治疗严重哮喘儿童,对其肺功能的影响。方法:重度哮喘急性发作患儿40例,随机分为两组(n=20)。常规治疗组以雾化吸入2β受体激动剂、静脉滴注激素和氨茶碱为主;镁联合组在常规治疗基础上,辅以25 mg/kgMgSO4溶液静脉滴注和60 mg/mL MgSO4溶液雾化吸入。分别观察两组的疗效、住院天数和不良反应,以及治疗前和治疗后3 d肺功能、血镁、尿镁等指标的变化。结果:常规组哮喘缓解、住院天数明显长于镁联合组(P<0.05),其中治疗3 d后镁联合组哮喘缓解总有效率明显优于常规组(P<0.05)。镁剂造成的不良反应轻微,两组药物反应发生率无统计学意义。治疗3 d后两组患儿的用力肺活量、1 s用力呼气量、呼气高峰流量均较治疗前明显改善,但镁联合组的肺功能明显优于常规组(P<0.05)。两组治疗前和3 d后的血镁变化无显著性差异,3 d后镁联合组的尿镁与肌酐浓度比值高于常规组(P<0.05)。结论:镁离子溶液辅助治疗儿童重度哮喘安全有效,可明显改善患儿的肺功能。
Objective： To investigate the influence of magnesium sulfate as an adjunctive treatment on the lung function of children with severe asthma. Methods： Forty children with severe asthmatic status were randomly divided into 2 groups （n=20）. The routine group was mainly subjected to β2 receptor agitator （albuterol） inhalation, glucocorticoid and aminophylline intravenously as control; Mg group were treated with 25 mg/kg MgSO4 intravenously and 60 mg/mL MgSO4 inhalation, based on routine therapy. Their therapeutic effectiveness was observed including hospital staying, drug side-effects, their lung function, serum magnesium and urinal magnesium levels before and after 3 d treatment. Results： The duration of asthma remission and hospital in routine group were longer than that of Mg group （P〈0.05）.The total effective rate in Mg group was higher than that of control （P〈0.05）. after 3 d. The side-effects of magnesium sulfate were mild, and there was no statistical difference between two groups. Compared with their lung function before therapy, the forced vital capacity（FVC）, ls forced expiratory volume（FEV1） and peek expiratory flow rate （PEFR） in two groups improved; but the level of lung function in Mg group was significantly dominant than the routine group （P〈0.05）.The serum magnesium had no change in two groups before and after 3 d treatment. The ratio of urine magnesium to creatinine in Mg group was higher than that of the routine group after 3 d treatment （P〈0.05）. Conclusion： Magnesium sulfate as an adjunctive therapy for children with severe asthma is effective and safe, and improves their lung function obviously.
出处
《海南医学院学报》
CAS
2006年第4期300-303,共4页
Journal of Hainan Medical University
关键词
哮喘
硫酸镁
肺活量
呼气功能试验
儿童
Asthma
Magnesium sulfate
Lung vital capacity
Test of expiratory function
Children
