摘要
目的:探讨血清CA19-9对胆囊癌的诊断及疗效判断价值。方法:采用化学发光法对胆囊癌、胆囊良性病变及良性非胆系疾病患者共60例进行手术前后血清CA19-9检测。结果:胆囊癌患者术前血清CA19-9水平明显高于胆囊良性病变者(P<0．01),检测的敏感性为80．0％,特异性为97．5％。胆囊癌根治性手术后血清CA19-9水平较术前有显著降低(P <0．01),而姑息性手术前后无显著变化。结论:手术前后血清CA19-9水平的检测,对胆囊癌的诊断及疗效判断具有较高的临床应用价值。
Objective：To investigate the value of serum carbohydrate antigen 19-9 （CA19-9） level in the diagnosis and treatment of gallbladder cancer patients. Methods.. Serum CA19-9 was measured by using chemiluminescence ashy before and after operation in 20 patients with benign gallbladder disease, 20 patients with malignant gallbladder disease, and 20 patients without gallbladder disease. Results： The preoperative serum CA19-9 level in patients with gallbladder cancer was significantly higher than that of benign gallbladder diseases （P〈0.01）. The sensitivity and specificity of preoperative serum CA19-9 level for the diagnosis of gallbladder cancer was 80. 0% and 97. 5%, respectively. The serum CA19-9 level after tumor radical resection in patients with gallbladder cancer significantly decreased from preoperative to postoperative（487. 9 ± 542. 5μ/ml vs. 130. 1 ± 136. 1 μ/ml ,P〈0. 01 ）, whereas the serum CA19-9 level did not significantly changed after tumor palliative resection compared with that of pre-operation. Conclusion.. Serum CA19-9 level is an effective tumor marker in diagnosing gallbladder cancer and deciding whether the tumor has been radically resected.
出处
《中国临床医学》
北大核心
2006年第4期591-592,共2页
Chinese Journal of Clinical Medicine
