摘要
目的:探讨国产镍钛记忆合金血管内支架及带聚氨酯膜内支架的生物相容性和影响内支架通畅的因素。方法:采用三类支架,健康犬21只,导入支架43个,其中裸支架22个,带膜支架21个。支架置入后即时、6周、2、3、4个月行血管造影,并对支架区血管行大体病理、光镜、扫描及透射电镜检查。结果:43个支架均成功导入靶区,裸支架开通率为100％(20／20),完全通畅率为80％(16／20)。带膜支架开通率为5.26％(1／19),狭窄率为31.6％(6／19),闭塞率为63．2％(12／19)。裸支架比部分包被支架通畅率高,两者之间差异具有统计学意义(P<0．05)。裸支架亦比全包被支架通畅率高,两者之间差异具有显著统计学意义(P<0.01)。光镜和电镜检查结果:各期裸支架表面皆被内膜覆盖,电镜下见排列整齐的内皮细胞。带膜支架狭窄者可见支架内血栓,血栓内为较厚的增生内膜。结论:国产镍钛记忆合金血管裸支架植入容易,生物相容性好。聚氨酯膜内支架易导致血管成形术部位急性血栓形成及内膜增生,生物相容性差。
Objective： to investigate the biocompatibility of the domestic nitinol alloy stent and polyurethane covered nitinol stent, factors for the prevention of stent restenosis due to intimal hyperplasia. Methods：Three kind of stent and 21 healthy dogs were used for this study. 22 noncoated stents, 21 coated stents were positioned in the target area and expand. Angiography was performed 6 weeks, 2,3,4 months respectively. All dogs were killed and taken pathological examination. Specimens were stained with hematoxylin-eosin（HE）. Histological slides were analyzed microscopically and by a video system Neointimal thickness was measured. Results：43 stents were implanted into target vessels. 20/20 noncoated stents were patent and of which 16 stents were completely patent. 1/19 coated stent was patent, 6/19 were stenosis and 12/19 were occlusion. Noncoated stents proved to have a high patent rate than coated stents （P〈0. 05）. All noncoated stents remained patent, there were no signs of thrombosis macroscopieally. All coated stents showed luminal reduction or occlusion due to vessel wall thicking and thrombosis. Conclusion：the preliminary results demonstrate that the domestic nitinol alloy intravascular noncoated stems are promising with good geometrical compliance, biocompatibility and physicochemical stability, The stents coated by polyurethane membrane caused acute thrombosis and neointimal proliferation.
出处
《中国临床医学》
北大核心
2006年第4期542-544,共3页
Chinese Journal of Clinical Medicine
