摘要
昆虫NF-κB信号通路由toll和imd两条通路组成,通过转录因子NF-κB作用于靶标基因κB位点,而调节抗菌活性物质的表达。大量实验表明它能够被细菌、真菌和病毒的侵染所激活,在昆虫体液免疫中发挥着主要作用。现就昆虫的NF-κB信号通路的主要信号元件等进行综述。
In insects, the NF-kB signal pathway, being composed of toll path and imd path, regulates the expression of antimicrobial genes as NF-kB factors binding kB sequence of targeted genes. Evidences have proved that this pathway plays a vital role in insect innate immunity, and can be triggered by proinflammatory microbes and viruses. In this article, the signal elements of this signal pathway in insects are reviewed mainly.
出处
《细胞生物学杂志》
CSCD
2006年第4期561-565,共5页
Chinese Journal of Cell Biology
