摘要
Fas/CD95作为肿瘤坏死因子(TNF)/神经生长因子(NGF)分子受体超家族成员,在细胞凋亡及体内免疫调节方面发挥重要的作用。细胞在接收到经Fas传递的凋亡信号后,主要经胞浆caspase和线粒体两种途径引发细胞程序性死亡。Fas介导T/B淋巴细胞的凋亡,在这些细胞的早期分化发育和维持机体免疫平衡中起主要作用。CTL和NK等杀伤细胞也通过Fas-FasL介导的细胞凋亡而发挥对靶细胞的杀伤效应。因此,Fas-FasL系统在肿瘤、自身免疫性疾病、艾滋病等疾病过程中发挥重要的作用。
As a member of the Fas （CD95） plays an important role in tumor necrosis factor （TNF）/nerve apoptosis and immunoregulation. growth factor （NGF） receptor superfamily, Once Fas binds with its ligand, known as Fas ligand, the cells expressing Fas goes to program cell death or apoptosis. Apoptosis mediated by Fas-FasL involves in the clonal deletion of T cell and B cell in thymus and bone marrow at the early stage of the cell＇s differentiation. CTL and NK kill their target cells by Fas and FasL interaction. So the Fas and FasL are very important elements in maintaining immune system homeostasis of the human body and involved in autoimmune disorders, tumor development and acquired immune deficiency syndrome.
出处
《细胞生物学杂志》
CSCD
2006年第4期543-546,共4页
Chinese Journal of Cell Biology
基金
上海市科委重大项目(No.03DJ14009
No.05ZR14055
No.054319928)
上海市教委项目(No.T0206
No.05BZ26)资助~~
