摘要
近年来,自然杀伤(NK)细胞和树突状细胞(DCs)的相互作用逐渐成为免疫学领域的一个研究热点。越来越多的实验表明,两种细胞可通过细胞-细胞接触并分泌细胞因子在炎症组织和次级淋巴结中相互作用,在机体抗肿瘤、抗病毒及抗移植排斥等效应中发挥重要作用。现对NK细胞和DCs相互作用及生物学意义等方面的研究进展进行综述。
The functional links between natural killer （NK） cells and dendritic cells （DCs） have been extensively investigated in recent years. By secreting cytokines and through cell-to-cell contact manner, NK cells and DCs can interact with each other in inflamed tissues and second lymphoid organs, which process is involved in anti-tumor, anti-viral effects and transplantation rejection. Here we reviewed the process they interact and the biological functions they exhibit in innate and adaptive immune responses.
出处
《细胞生物学杂志》
CSCD
2006年第4期530-534,共5页
Chinese Journal of Cell Biology
基金
国家自然科学基金海外青年学者合作研究基金(No.30328011)~~
关键词
自然杀伤细胞
树突状细胞
相互作用
抗肿瘤效应
抗病毒效应
nature killer cells
dendritic cells
reciprocal interactions
anti-tumor effects
anti-viral effects
