摘要
高迁移率族蛋白(highmobilitygroupprotein,HMG蛋白)广泛存在于真核生物细胞中,因其在聚丙稀凝胶电泳中的高迁移率而得名。HMG蛋白是真核细胞基因调控的动力体现者,是真核细胞内继组蛋白之后含量最为丰富的一组染色质蛋白质,它们在染色质的结构与功能及基因表达调控过程中均发挥着重要作用。HMG蛋白家族可分为HMGA、HMGB和HMGN三类亚家族。现对HMG蛋白家族的三类亚家族蛋白HMGA、HMGB和HMGN的结构与功能进行综述。
High mobility group （HMG） proteins exsit in eukaryotic cells widely named according to their high electrophoretic mobility on SDS-PAGE. The HMG protein family is dynamical player in gene regulation in eukaryote. The HMG protein family is, after histones, the second most abundant chromatin protein and exerts global genomic functions in the chromatin composition and gene expression. The HMG protein family is subdivided into three subfamilies： the HMGA subfamily, the HMGB subfamily and HMGN subfamily. This article mostly discusses the structures and functions of the three subfamilies.
出处
《细胞生物学杂志》
CSCD
2006年第4期501-506,共6页
Chinese Journal of Cell Biology
