摘要
目的观察静脉应用胺碘酮治疗急性心肌梗死(AMI)并心房颤动(AF)的临床疗效及安全性。方法对33例AMI并AF患者,先用胺碘酮静脉注射负荷量后,继以静脉滴注维持。观察房颤转复、血压、心室率以及不良反应。结果AF转复率2h内为42.4%(14/33),24h内为66.7%(22/33),48h内为84.9%(28/33),72h内为87.9%(29/33)。用药24h后心室率明显下降,与治疗前比较有显著性差异(P<0.001)。用药前后血压变化不明显(P>0.05)。2例用药后出现长R-R间期,2例出现窦性心动过缓,经停药或减量恢复。结论静脉应用胺碘酮治疗AMI并AF安全、有效,值得临床推广应用。
Objective To investigate the efficacy and safety of amiodarone in treatment of acute myocardial infarction （AMI） with atrial fibrillation（AF）.Methods Thirty-three AMI cases with AF were observed. After a load dose, intravous amiodarone administered continuously. Efficacy of amiodarone in the reversion of AF, blood pressure（BP）, the control of ventricular rate and the side effects were observed. Results AF was reverted to sinus rhythm with 2 hours in 14 of 33 cases（42.4%）, with 24 hours in 22 of 33 cases（66.7%）, with 48 hours in 28 of 33 cases（84.9%）, with 72 hours in 29 of 33 cases（87. 94%）. The ventricular rate after treatment for 24 hours was significantly lowered than that of before treatment （P〈0.001）. The BP had no significant change before and after treatment （P〉0. 05）. Long R- R intermitment observed in 2 cases, sinus bradycardia was occurred in 2 cases, cardiac rhythm in all patients returned to normal after reducing the dose or ceasing the medicine. Conclusion Intravenous amiodarone in treatment of AMI with AF is effective and safe, and it can be widely used in clinic.
出处
《国际医药卫生导报》
2006年第17期124-126,共3页
International Medicine and Health Guidance News
关键词
急性心肌梗死
胺碘酮
心房颤动
Acute myocardial infarction Amiodarone Atrial fibrillation
