摘要
Isoflurane has the dual effects on nociceptive stimulation. It produces hyperalgeia at low partial pressure (0.1 MAC), while displays an antinociceptive effect at higher concentrations (0.4 MAC^0.6 MAC). The different actions of isoflurane on Aδ and C fibers of the spinal cord, and the neuronal nicotinic acetylchlorine receptors (nAChRs), adrenoceptors (including α1 and α2 receptors), excitatory neuronal synaptic transmission ( NMDAergic and AMPAergic), and inhibitory neuronal synaptic transmission ( GABAergic and glycinergic), substance P, and c-fos gene in the central never system may contribute to the mechanisms of isoflurane’s dual effects.
Isoflurane has the dual effects on nociceptive stimulation. It produces hyperalgeia at low partial pressure （0. 1 MAC ）, while displays an antinociceptive effect at higher concentrations （0.4 MAC -0.6 MAC ）. The different actions of isoflurane on Aδ and C fibers of the spinal cord, and the neuronal nicotinic acetylchlorine receptors （nAChRs）, adrenoceptors （including α1 and α2 receptors）, excitatory neuronal synaptic transmission （ NMDAergic and AMPAergic）, and inhibitory neuronal synaptic transmission （ GABAergic and glycinergic）, substance P, and c-fos gene in the central never system may contribute to the mechanisms of isoflurane＇ s dual effects.
出处
《国际麻醉学与复苏杂志》
CAS
2006年第4期252-255,共4页
International Journal of Anesthesiology and Resuscitation
