摘要
树突细胞(dendriticcell,DC)识别上皮细胞或黏膜表面的抗原,通过其细胞内受体或吞噬细胞受体捕获它们,经加工处理后转移至淋巴组织。在淋巴结内,它们把免疫源性肽提呈给T细胞,从而引发特异性的免疫应答。DC_SIGN是表达于DC表面的蛋白质,它在病毒由DC向T细胞的传递过程中发挥了重要作用。HIV_1反过来也利用DC之间的自然交通来感染原初靶细胞CD4+T细胞。这篇综述主要讨论了DC、DC_SIGN与HIV感染的相互作用。
Dendritic cell（DC） survey epithelial or mueosal surfaces for antigens, take them up via their endocytie or phagocytic receptors, process the captured antigens and migrate to the lymphatic tissues. In the lymph nodes, they present the immunogenie peptides to T cells thereby inducing antigen-specific immune responses. DC-SIGN is a protein expressed on the surface of DC, playing an important role in the transmission of the virus by DC to T cells. HIV-1 in turn develops mechanisms to exploit the natural trafficking of DC to establish infection in its primary targets, the CD4^＋ T cells. This review discusses mainly about the interaction of DC, DC-SIGN and HIV infection.
出处
《国际流行病学传染病学杂志》
CAS
2006年第4期261-264,共4页
International Journal of Epidemiology and Infectious Disease
