摘要
Objective:To determine outcome of delivery before 36 weeks gestation in babie s diagnosed antenatally with serious congenital heart disease(CHD).Study desig n:A retrospective database review at 2 tertiary care fetal cardiology centers.Details of neonatal course and outcome were obtained for those antenatally diagn osed with serious CHD who were live born before 36 weeks gestation.Results:Bet ween January 1998 and December 2002,9918 women were referred for fetal echocard iography.Serious CHD was diagnosed in 1191 fetuses(12%),of which 46(4%)de livered prematurely.Median gestation was 33(range 24-35)weeks,and median bi rth weight 1.56(0.50-3.59)kg.Extracardiac/karyotypic anomalies occurred in 23(50%).Twenty-six babies(57%)underwent neonatal surgery:16 a cardiac pr ocedure,5 a general surgical procedure,and 5 both.Eight died during or after operation(31%).Two babies underwent interventional heart catheterization;bot h died.The overall mortality rate was 72%.Extracardiac/karyotypic anomalies i ncreased the relative risk of death by a factor of 1.36.Mean hospital stay for those surviving to initial discharge was 46(2-137)days.Conclusions:There is a very high morbidity and mortality rate in this group,particularly for those with extracardiac/karyotypic anomalies.This should be reflected in decisions ov er elective preterm delivery and when counseling parents.
Objective： To determine outcome of delivery before 36 weeks gestation in babies diagnosed antenatally with serious congenital heart disease （CHD） . Study design： A retrospective database review at 2 tertiary care fetal cardiology centers. Details of neonatal course and outcome were obtained for those antenatally diagnosed with serious CHD who were live born before 36 weeks gestation. Results： Between January 1998 and December 2002, 9918 women were referred for fetal echocardiography. Serious CHD was diagnosed in 1191 fetuses （12%）, of which 46 （4%） delivered prematurely. Median gestation was 33 （range 24 -35） weeks, and median birth weight 1.56 （0. 50 - 3.59） kg. Extracardiac/ karyotypic anomalies occurred in 23 （50%）. Twenty-six babies （57%） underwent neonatal surgery： 16 a cardiac procedure, 5 a general surgical procedure, and 5 both. Eight died during or after operation （31%） Two babies underwent interventional heart catheterization; both died. The overall mortality rate was 72%. Extracardiac/karyotypic anomalies increased the relative risk of death by a factor of 1.36.
