摘要
目的：了解肝豆状核变性（hepatolentieular degeneration，HLD）患者的免疫状态特点。方法：选取正常对照组19名及HLD患者21例，散射比浊法和流式细胞术分别测定血清免疫球蛋白、补体水平及外周静脉全血T淋巴细胞亚群、CD3^-CD16^＋CD56^＋、CD19^＋计数。结果：HLD患者体液免疫指标中CD19^＋、IgG、IgM均较正常组升高，C4较正常组减低（P〈0．05～P〈0．01）；细胞免疫指标CD4’、CD4’／CD8’、CD3一CDl6’CD56’均较正常组减低，CD8’升高（P〈0．05～P〈0．01）。结论：HLD患者的免疫状态紊乱表现为体液免疫处于亢进状态，细胞免疫低下。
Objective ：To study the immunological characteristics of patients with hepatolenticular degeneration （HLD）. Methods：The levels of serum immunoglobulins, complement and T-lymphocyte subsets, the indexes of the humoral immunity and the propotion of CD19^＋ in 21 patients with HLD and 19 normal controls were measured with immune turbidimetry and flow cytometry. Results： The levels of IgG and IgM in group HLD were increased compared with the controls, except for C4, which was depressed （ P 〈 0. 05 - P 〈 0.01 ） ,together with the ratio of CD4^＋/CD8^＋ , the propotion of CD3^- CD16 ^＋ CD56^＋, CD4^＋ increased （ P 〈 0. 05 - P 〈 0.01 ） . Conclusions：The study showed that there was disorder of the immunological state in patients with HLD, and suggests the manifestation of which is activation of the humoral immunity and depression of the cellular immunity.
出处
《蚌埠医学院学报》
CAS
2006年第5期456-458,共3页
Journal of Bengbu Medical College
关键词
肝豆状核变性
免疫
体液
免疫
细胞
流式细胞术
hepatolenticular degeneration
immunity, humoral
immunity, cellular
flow cytometry
