摘要
目的探讨e抗原阴性的慢性肝病(包括慢性肝炎、肝硬化、肝癌)患者血清HBV-DNA含量与血清谷丙转氨酶(ALT)及谷草转氨酶/谷丙转氨酶(AST/ALT)比值的相关性。方法应用聚合酶链反应(PCR)技术检测91例e抗原阴性的慢性肝病患者血清HBV-DNA含量,全自动生化分析仪测定ALT、AST/ALT指标。结果91例e抗原阴性的慢性肝病患者血清HBV-DNA含量平均为1.24×105copies/ml;血清ALT水平平均为326IU/L;血清AST/ALT平均为1.15;血清HBV-DNA含量与ALT之间无相关性(r=-0.43、P>0.05);与血清AST/ALT成明显负相关(r=-0.314、P<0.01)。结论血清HBV-DNA含量由高到低变化与肝细胞损伤及损伤程度无关,但在一定程度上可以较好地评价e抗原阴性的慢性肝病患者的病情进展。提示疾病会向不良方向转归。
Objective To explore the correlation between the level of serum HBV DNA and ALT or AST/ALT. Methods Ninety-one cases of chronic hepatic diseases with HbeAg negative were examined with a polymerase chain reaction （PCR） technique for the HBV-DNA level detection, and the result of ALT、AST/ALT were examinded with auto biochemical analyzing machine. Results The average level of HBV DNA was 1.24×10^5 copies/ml, serum ALT were 326 IU/L, serum AST/ALT were 1.15; There was no correlation between HBV DNA level and ALT（r=-0.043, P〈0.05）; the negative correlation with AST/ALT was obvious （r=-0.314, P〈0.01）. Conclusion The variety of high to low level of HBV DNA is not associated with hepatic cell lesion and their degrees, but in degree can evaluate the advance of diseases in the patients with chronic hepatic diseases of HbeAg negaive, and indicates illness situation toward adverse progress.
出处
《基层医学论坛》
2006年第9期781-782,共2页
The Medical Forum
关键词
乙型肝炎病毒
E抗原阴性
肝功能指标
聚合酶链反应
Hepatitis B Virus （HBV） HbeAg-negative Hepatic Function Indices Polymerase Chain Reaction（PCR）
