摘要
目的:以聚乳酸为载体材料制备阿奇霉素微球(AZM-MS)并考察其体外释药特性。方法:采用乳化-溶剂挥发法制备AZM-MS,并对其形态、粒径、包封率、结构和质量、体外释药特性等进行研究。结果:微球外观形态为类球形实体,粒径分布较均匀,平均粒径dav=(20.8±0.5)μm,三批载药微球的包封率为(68.3±1.28)%;体外释药符合Higuchi方程,差示扫描热分析证明微球的形成。结论:本实验筛选的最佳处方工艺可制备性质优良的阿奇霉素肺靶向聚乳酸微球。
Objective： To prepare microsphere containing Azithromycin（AZM） with polylactic acid, and investigate the characteristics of AZM microsphere （AZM-MS）in vitro release. Methods： AZM-MS was prepared by emulsion solution-evaporation, and its morphology and particle size were examined by light electron microscope. Entrapment ratio, structural properties, quality and the release of AZM in vitro were studied. Results： The AZM-MS assumed spherical shape. Its distribution of particle diameter was even with an average particle size of（20.8 ± 0.5） nm. The entrapment ratio was（68.3 ± 1.29） %. The release of AZM-MS in vitro conformed to Higuchi Equation. The formation of a new material phase was testified by differential scanning calorimetry（DSC）. Conclusion： AZM-MS is a good lung-targeting drug release system.
出处
《山东大学学报（医学版）》
CAS
北大核心
2006年第8期853-856,共4页
Journal of Shandong University:Health Sciences
关键词
阿奇霉素
聚乳酸
微球
Azithromycin
Polylacfic acid
Microsphere
