摘要
目的:比较前稀释高容量联机血液滤过(HF)与低通量血液透析(HD)清除的效果。方法:对10例维持性HD患者采用前瞻性、随机、交叉研究,观察两种血液净化治疗前后血清肌酐(Scr)、血尿素氮(BUN)、血磷、β2微球蛋白(β2-MG)、瘦素(leptin)水平变化及评价尿素清除指数。结果:HF组β2-MG、瘦素下降率明显高于HD组(P<0.01),而BUN、Scr下降率及一室尿素清除指数、二室尿素清除指数低于HD组(P<0.05)。两组血磷下降率差异无显著性。结论:前稀释高容量联机HF清除较大分子量尿毒症毒素明显优于低通量HD。
Objective To compare the clearance effect of pre-dilution high volume on-line hereofiltration （HF）with that of low permeable hemodialysis（HD） . Methods 10 uremic patients were included in this prospective cross-over study. They were randomly administered with either pre-dilution high volume on-line hemofiltration or low permeable hemodialysis and their serum levels of creatinine, blood urea nitrogen, phosphate, β2-microglobulin, and leptin were observed before and after the two different procedures. Kt/V was evaluated. Results Compared with those in the patients undergoing HD, serum β2-microglobulin and leptin in the patients undergoing HF were significantly decreased（ P 〈 0.01 ）, whereas serum blood urea nitrogen, creatinine, KT/Vsp and KT/Vdp were lower（ P 〈 0. 05）. There was no significant difference in serum phosphate between the patients undergoing HF and HD. Conclusion Pre-dilution high volume on-line bemofiltration are markedly superior to low permeable hemodialysis in the clearance of larger uremic toxin molecules.
出处
《实用医学杂志》
CAS
2006年第17期1985-1987,共3页
The Journal of Practical Medicine
关键词
血液滤过
肾透析
交叉研究
Hemofiltration Renal dialysis Corss-over study
