摘要
目的:探讨复方败酱颗粒对慢性结肠炎的治疗机理。方法:通过三硝基苯磺酸/已醇成功复制慢性结肠炎大鼠模型,应用复方败酱颗粒及5—氨基水杨酸分别灌胃治疗2周,测定结肠组织中超氧化物歧化酶(SOD)活力及丙二醛(MDA)含量。结果:复方败酱颗粒可明显升高模型大鼠SOD活力,降低MDA含量。结论:复方败酱颗粒通过抑制氧自由基反应干预了慢性结肠炎的发病过程。
Objective： To investigate the therapeutic mechanism of Compound Patrinia Granules（CPG） on chronic colitis. Method： The rat models of chronic colitis were set up by trinitro - benzene - sulfonic aeid（TNBS） and alcohol, the CPG and 5 - aminosalicylic acid were given to the models for 2 weeks respectively, after that, we determine the content of SOD and MDA in intestine tissue. Result： The CPG strengthened the activity of SOD and decreased the content of MDA. Conclusioni The CPG intervene in the occurrence process of chronic colitis by inhibiting the oxyradical reaction.
出处
《中医药导报》
2006年第8期88-89,共2页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
