摘要
目的:观察慢性应激和/或急性吗啡暴露(2mg/kg)对4周龄和10周龄大鼠记忆的影响。方法:建立平台应激模型,运用Morris水迷宫来观察慢性应激和急性吗啡暴露对4周龄和10周龄大鼠空间记忆的影响。结果:①4周龄组:吗啡组在目标象限停留的时间比对照组短(P<0.05)。慢性应激及慢性应激加吗啡组与对照组相比差异无显著性(P>0.05)。②10周龄组:慢性应激组、慢性应激加吗啡组在目标象限停留的时间均比对照组长(P<0.05)。而吗啡组与对照组相比差异无显著性(P>0.05)。③10周龄慢性应激组、吗啡组及慢性应激加吗啡组在目标象限停留的时间均比4周龄要长(P<0.05)。而对照组在两个年龄段比较差异无显著性(P>0.05)。两个年龄组中各组大鼠的运动速度分别与对照组相比差异无显著性(P>0.05)。结论:①慢性平台应激对10周龄大鼠记忆起易化作用,对4周龄没有明显的影响。②急性吗啡暴露(2mg/kg)对4周龄大鼠的记忆有损害作用,而对10周龄的记忆没有影响。③慢性应激加吗啡对4周龄大鼠的记忆无影响,对10周龄大鼠的记忆有易化作用。
Objective： To studyothe effects of chronic stress and acute morphine exposure （2mg/kg） on spatial memory in 4-and 10-week-old rats. Methods： Elevated platform stress protocol was established. Morris water maze was used to observe the effects of acute morphine exposure on spatial memory in 4-and 10-week-old stressed rats. Results： ①4- week-old rats： Rats of morphine group spent significantly less time in the target quadrani （TA） than those of control group （P〈0.05）. Time in the target quadrant did not differ in chronie stress group and chronic stress and morphine group compared with control （P 〉0.05）. ②10-week-old rats： Rats of chronic stress group and chronic stress and morphine group spent significantly more time in the target quadrant than those of control group （P〈0.05）; Time in the target quadrant did not differ in morphine group compared with control group（P〉0.05）. ③Comparison between 10-week-old rats and 4-week- old rats： 10-week-old rats in chronic stress group, chronic stress and morphine group and morphine group spent significantly more time in the target quadrant than that of 4-week-old rats in the Same groups, respectively （P〈0.05）.Time in the target quadrant did not differ in control group between 4-week-old rats and 10-week-old rats （P 〉0.05）.Swimming speed did not differ in all groups of 4-or 10-week-old rats （P 〉0.05）. Conclusion：①Chronic stress induces enhancement of memory retention in 10-week-old rats and has no effect on memory retrieval in 4-week-old rats. It shows difference between two age groups. ②Morphine in the dose of 2mg/kg induces impairment of memory retention in 4-week-old rats and has no effect on memory retention in 10-week-old rats. It shows difference between two age groups. ③Chronic stress and morphine has no effect on memory retention in 4-week--old rats and induces enhancement of memory retention in 10-week-old rats. It also shows difference between two different ages.
出处
《中国临床心理学杂志》
CSCD
2006年第4期431-434,共4页
Chinese Journal of Clinical Psychology
基金
国家自然科学基金(项目号:30370522)
973项目(项目号:2003CB5154004)
