摘要
目的多因素评价动脉化疗栓塞治疗原发性肝癌的疗效及预后影响。方法对127例中晚期肝癌治疗有效率行单因素分析,对预后影响行cox回归分析。结果治疗有效率有意义的影响因素为治疗方法、肿块类型、肿瘤血供、肝功能、门脉癌栓、碘化油沉积。预后有意义的影响因素为肝功能、门脉癌栓、治疗次数、碘化油沉积、治疗间隔期。结论血供丰富的巨块型肝癌,肝功能好且无门脉癌栓者行化疗栓塞疗效显著。肝功能差及门脉癌栓是预后危险因素,碘化油沉积、治疗次数、治疗间隔期是预后保护性因素。了解肝癌的预后因素对选择病例和治疗方法,提高疗效有积极意义。
Objective To evalunte efficacy of hepatic artery chemoembolization （HAE）in treatment of primary liver carcinoma（PLC） ,and to study the factors affecting the prognosis. Methods HAE was performed in 127 patients with advanced PLC, and the effectiveness was evaluated with univariate analysis. The Cox＇s regression analysis model was used to analyze the factors affecting the prognosis. Results The factors likely to affect the curative effectiveness were the way of treatment, tumor type, blood supply of the tumor, liver function, portal cancerous thrombus and lipiodol deposit. The main factors affecting the prognosis were the liver function, portal cancerous thrombus, times of treatment, lipiodol deposit and treatment interval. Conclusion The results suggest that HAE has special therapeutic value in treating those patients of massive hepatocareinoma with plentiful blood supply who had normal liver function and had not portal cancerous thrombus. Abnormal liver function and portal cancerous thrombus are risk factors affecting prognosis, while lipiodol deposit, times and interval of treatment are beneficial to the prognosis. To improve the therapeutic effectiveness, an understanding of the factors affecting the prognosis is very helpful for the physician to select suitable patients and proper treatment.
出处
《胃肠病学和肝病学杂志》
CAS
2006年第4期401-404,共4页
Chinese Journal of Gastroenterology and Hepatology
关键词
原发性肝癌
化疗栓塞
疗效
预后
回归分析
Primary liver carcinoma
Chemoembolization
Therapeutic effectiveness
Prognosis
Regression analysis
