摘要
目的探讨血管回声跟踪技术检测兔早期动脉粥样硬化的可行性、可靠性及应用价值。方法对30只新西兰雄性白兔进行高脂颗粒饲料喂养，分别在喂养0、4、6、8、10、12周末利用血管回声跟踪技术测量兔腹主动脉弹性的各种指标，包括弹性系数（Eρ）、硬度指数（β）、顺应性（AC）、膨大系数（AI）、脉搏波速度（PWV—β）；每次超声检查完成后随机处死4～6只兔做病理检查，测量腹主动脉内膜厚度，并将血管回声跟踪技术各种指标与病理做对照分析。结果①Eρ、β于4～10周末、PWVβ于6、10周末较基础状态明显增高（P〈0．05）；AC于4、6周末较基础状态明显减低（P〈0．05）；其余各指标差异均无统计学意义（P〉0．05）；AI无明显规律。②Eρ、β、PWV—β与内膜厚度有良好的相关性（P〈0．05）；AC、AI变化差异无统计学意义。结论血管回声跟踪技术评价早期动脉硬化、动脉弹性减低是准确、可信的，但斑块形成后上述指标可能出现偏差，可采用其他检查方法继续观察。
Objective To assess the feasibility, reliability and value of echo-tracking technology on early atherosclerosis in the rabbits models. Methods Thirty New Zealand rabbits were fed high cholesterol diet. The parameter of elasticity of abdorminal aorta were measured with echo-tracking technology, such as stiffness parameters（ β）, pressure-strain elastic modulus （ Eρ）, arterial compliance （ AC）, pulse wave velocity （ PWV-β）, augmentation index（AI） at the interval of 0,4,6,8, 10,12 weekend of the experiment. After each echo-tracking examination,4-6 rabbits were randomly killed and the corresponding sites of artery were gotten for histological examination. Intima thickness（IMT） were measured under the microscope. Results Eρ,β（4-10th week） and PWV-β（6,10th week） increased significantly （P 〈0. 05） with the experimental week, but AC reduced （4,6th week） compared with the basement. The IMT increased simultaneously. The measurements by two methods （the parameter of echo-tracking and IMT） had a good correlation in Eρ, β and PWV-β. Conclusions Echo-tracking technology provides an accurate, non-invasive and reliable method in detecting early atherosclerosis and monitoring the progression. But the bias maybe appeared after the plaques were found in the wall of arteries.
出处
《中华超声影像学杂志》
CSCD
2006年第8期617-620,共4页
Chinese Journal of Ultrasonography
关键词
超声检查
动脉硬化
主动脉
腹
兔
Ultrasonography
Atherosclerosis
Aorta,abdominal
Rabbits
