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静脉溶栓治疗急性脑梗死的临床观察

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摘要 目的观察大剂量尿激酶治疗脑梗死超早期的静脉溶栓效果。方法对40例符合溶栓条件的急性脑梗死病人在发病6h内给予尿激酶100万U静滴,辅以低分子右旋糖酐500ml/d,内加脉络宁针20ml,连用15d,溶栓有效者,次日起给予低分子肝素2500U,Bid,iH连用5—7d。对照组不用尿激酶,只用低分子右旋糖酐、脉络宁及低分子肝素等药物,用法及用量同溶栓组,适当给予甘露醇脱水降颅压治疗。结果溶栓治疗40例,第21d基本痊愈12例,占30.0%,显著进步21例,占52.5%,总显效率为82.5%(33/40)。对照组42例,基本痊愈10例,显著进步10例,各占23.8%,总显效率为47.6%。两组间比较差异有统计学意义(P〈0.05),溶栓组出血率为10%(4/40),脑内出血占5%(2/40),对照组出血率为5%(2/40),全为颅内出血。结论大剂量尿激酶超早期(6h以内)静脉溶栓治疗急性脑梗死有效。
出处 《临床医学》 CAS 2006年第8期29-30,共2页 Clinical Medicine
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