摘要
目的：探讨阿立哌唑在中国精神分裂症病人体内的血药浓度与临床疗效的关系。方法：采用高效液相色谱-质谱联用(HPLC-MS)的方法测定30例精神分裂症病人体内阿立哌唑的血浆药物浓度,疗效评定采用阳性与阴性症状量表(PANSS)评分,用SPSS 11．0统计软件包对血药浓度与疗效评分进行统计分析。结果：治疗wk1,2,3,4末的阿立哌唑血药峰浓度与wk 1,2,3,4末的PANSS减分率无相关性,而wk 3,4末的平均稳态谷浓度与wk 4末的PANSS减分率呈正相关(r＞0．500,P＜0．05)。同时,将稳态血药谷浓度分为小于350．0μg·L^(-1)组和大于350．0μg·L^(-1)组病人的疗效进行比较,结果前者的PANSS减分率明显低于后者,两者的差异有统计学意义(P＜0．05)。结论：根据本实验研究结果,初步得出阿立哌唑的临床疗效与其稳态谷浓度高低有关,其稳态谷浓度在350．0μg·L^(-1)以上时,疗效较好。
AIM： To study the aripiprazole for Chinese schizophrenics. relationship between plasma concentration and clinical efficacy of METHODS： Aripiprazole plasma sample concertations were determined by HPLC-MS, efficacy was measured by the Positive and Negative Syndrome Scale （PANSS） scores, and the relationship between plasma concentration and clinical efficacy of aripiprazole was conducted by SPSS 11.0. RESULTS： The peak concentrations of aripiprazole on the weekends 1, 2, 3, 4 were not correlative with the decreased ratios of PANSS scores, which were positive correlation with the average steady state trough tions of aripiprazole in weekends 3 and 4 （r 〉 0.500, P 〈 0.05） . The PANSS scores at the concentration above 350.0μg·L^-1 decreased significantly comparing with the lower concentration （P 〈 0.05） . CONCLUSION： The steady state trough concentrations of aripiprazole are correlative with the efficacy scores, with better results above 350.0μg·L^-1.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2006年第8期601-605,共5页
Chinese Journal of New Drugs and Clinical Remedies
