摘要
目的:研究电磁脉冲(electromagnetic pulse,EMP)对海马组织中N-甲基-D-天冬氨酸受体(N- methyl-D-aspartate receptor,NMDAR)白表达的影响。方法:采用Western blotting蛋白印迹法,对EMP照射前后海马组织中NMDAR的蛋白表达进行检测。结果:EMP照后1h NMDAR蛋白表达升高,持续至24h达最高点(与对照组相比,P<0．05),之后回降。结论:在电磁脉冲照射后早期,中枢神经系统内存在有效的代偿机制,合成新的受体分子以适应功能的需要。
Objective：To explore the effect of EMP on the expression of N-methyl-D-aspartate receptor （NMDAR）protein in hippocampus in rats. Methods. Western blotting was applied to detect the expression of NMDAR protein in hippocampus before and after EMP exposure. Results： The NMDAR protein increased at 1h and reached the highest level at 24h after exposure（compared with control,P〈0. 05）, and decreased after that. Conclusions： There is a efficient compensatory mechanism by which new NMDAR protein can be synthesised to suit functions in central nervous system early after exposure.
出处
《承德医学院学报》
2006年第3期237-239,共3页
Journal of Chengde Medical University
