摘要
目的:探讨单纯甲亢和甲亢合并肺动脉高压患者的血浆肾上腺髓质素(ADM)的含量变化及其意义。并分析血浆ADM与血清甲状腺激素之间的相关关系。方法:用放射免疫分析(Rad ioimmunoassay,R IA)测定30例单纯甲亢患者、27例甲亢合并肺动脉高压患者和32例健康对照组的血浆ADM。化学发光法测定甲状腺激素。结果:①57例甲亢患者中27例合并肺动脉高压,甲亢继发肺动脉高压的发生率为47.37%。②甲亢合并肺动脉高压组血浆ADM较单纯甲亢组和健康对照组血浆ADM均显著增高,P<0.01。单纯甲亢组的ADM较健康对照组增高,P<0.05。③Pearson相关分析显示,健康对照组血浆ADM与FT3、FT4无相关性,单纯甲亢组、甲亢合并肺动脉高压组血浆ADM与FT3、FT4呈正相关。结论:肺动脉高压是甲亢常见的一种血流动力学改变,甲亢患者的血浆ADM浓度较健康对照组增高,甲亢合并肺动脉高压的患者血浆ADM浓度更高,ADM浓度明显增高的甲亢患者应警惕肺动脉高压。甲状腺激素可能影响ADM的产生。
Objective To investigate the plasma adrenomedullin （ADM） concentrations in hyperthyroid patients with or without pulmonary hypertension. Methods Plasma ADM levels were measured with RIA in： ① 30 hyperthyroid patients without pulmonary hypertension, ② 27 hyperthyroid patients with pulmonary hypertension, and ③ 32 controls. Results ① In this study, 27 of the 57 hyperthyroid patients were complicated with pulmonary hypertension （47.37%）, ② Plasma ADM concentrations in the patients with pulmonary hypertension were significantly higher than those in patients without pulmonary hypertension and controls （P 〈 0.01 ）, ③ In the hyperthyroid patients, levels of T3 , T4 （ thyroid hormones） were positively correlated with those of ADM while there were no correlations in controls. Conclusion Plasma ADM concentrations increased in hyperthyroid patients, especially in those complicated with pulmonary hypertension. The clinicians should look for pulmonary hypertension in hyperthyroid patients with substantially elevated levels of ADM.
出处
《放射免疫学杂志》
CAS
2006年第4期283-285,共3页
Journal of Radioimmanology
关键词
甲亢
肺动脉高压
肾上腺髓质素
hyperthyroidism, pulmonary hypertension, adrenomedullin（ADM）
