摘要
目的:探讨糖尿病肾病(DN)患者血、尿Ⅳ型胶原变化及其与肾小球滤过率的关系。方法:采用放射免疫分析测定30例对照组及136例2型糖尿病患者血、尿Ⅳ型胶原浓度,并与由SPECT法测得的肾小球滤过率(GFR)进行比较。结果:糖尿病患者血、尿Ⅳ型胶原浓度均高于正常人,DN患者进一步增高,且与病情严重程度有关。DN初期尿白蛋白浓度正常时,血、尿Ⅳ型胶原及GFR已明显升高(分别为98.2±43.5ng/m l,86.7±35.6ng/m l和135.6±41.4m l/m in);经降糖治疗后血ⅣC浓度有不同程度的降低。结论:血、尿Ⅳ型胶原检测可用于DN的早期诊断及预后判断。
Objective To investigate the changes of serum or urinary typeiv collagen concentration and GFR in patients with diabetic nephropathy （DN）. Methods Serum or urine typeiv collagen concentrations （with RIA） and GFR （with SPECT） were determined in 136 DM2 patients with various degrees of albuminuria as well as in 30 controls. Results Both the serum and urine typeiv collagen concentrations were significantly higher in the diabetic patients than those in the controls, and the levels increased continuously as the renal involvement progressed （albuminuria from 〈 20μg/min→〉 200μg/min）. The elevation of serum or urinary type Ⅳ collagen occurred early, even before the increase of albuminuria. The GFR at this early stage was paradoxically higher than normal （135. 6±41.4ml/min）. Later, with progression of nephropathy, the albuminuria and serum/urine type Ⅳ collagen contents increased continuously but the GFR decreased to very low level. Successful control of blood sugar might reverse the increase of type Ⅳ collagen to certain degree. Conclusion Determination of serum/urinary type Ⅳ collagen levels might be useful for early diagnosis and assessment of severity of the nephropathy complicating DM2.
出处
《放射免疫学杂志》
CAS
2006年第4期273-274,共2页
Journal of Radioimmanology
