摘要
目的探讨以复视为首发症状的Lambert-Eaton肌无力综合征(LEMS)的临床特点。方法回顾性分析8例以复视为首发症状的LEMS患者的发病特点、临床表现及辅助检查。结果8例患者均为中老年人,以复视为首发症状,部分合并有睑肌无力。所有患者均经胸部CT或X线确诊为肺癌,3例患者经电刺激试验后显示高频重复电刺激波幅升高200%以上,6例(66.6%)手术后病理检查小细胞肺癌。结论对以复视为首发症状的中老年患者应考虑到Lambert-Eaton肌无力综合征的可能,常规行神经电刺激实验和简单的胸部CT或X线检查,可早期发现肿瘤并采取相应的治疗方案,以免漏诊和误诊。
Objective To discuss the clinical features of Lambert-Eaton myasthenia syndrome （LEMS） with the primary symptom of diplopia. Methods The clinical features, clinical manifestations and assistant examinations of 8 LEMS patients with the primary symptom of diplopia were analyzed retrospectively. Results The 8 patients were all old ones with the primary symptom of diplopia, some of them with ocular myasthenia gravis. All the patients were diagnosed as lung cancer through chest CT or X-ray. There were 3 patients that the amplitude of repeated electrical stimulation in high frequency had been increased over 200 % through the experiment of electrical stimulation. 6 patients were examined by pathology after the operation that 66.6% had small-cell lung cancer. Conclusions For the elderly patients with the primary symptom of diplopia, the doctors should consider the possibility of Lambert- Eaton myasthenia syndrome. The experiment of routine electrical nerve stimulation and the examination of simple chest CT or X-ray can find the cancer early and let the doctors adopt the corresponding therapy so as not to misdiagnosis and missed diagnosis.
出处
《神经疾病与精神卫生》
2006年第4期253-254,共2页
Journal of Neuroscience and Mental Health
